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KMID : 0829220140380030155
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Korean Journal of Oral and Maxillofacial Pathology
2014 Volume.38 No. 3 p.155 ~ p.164
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Relationship between Chronic Periodontitis and Oral Cancer in Oral Squamous Cell Carcinoma Patients
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박지은:Park Ji-Eun
박혜련:Pak Hae-Ryoun/이지혜:Lee Ji-Hye/김진범:Kim Jin-Bom
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Abstract
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Chronic inflammation has long been considered as an important contributing factor to the development of malignant tumors in various tissues. In this study, we aimed to investigate a potential association between chronic periodontitis, a representative inflammatory disease in the oral cavity, and oral squamous cell carcinoma (OSCC), the most common form of malignant tumors in the oral cavity. A retrospective study was designed to include the cases and controls, each of which consisted of patients first diagnosed with OSCC and temporomandibular disorders, respectively. The existence or a history of periodontal disease was quantitatively estimated based upon the level of alveolar bone loss (ABL) from panoramic radiographs in these groups. Unlike other covariates, including LDH, WBC count and hemoglobin, the levels of ABL measured at three independent regions (second premolar and first/second molar) were significantly higher in the OSCC group, regardless of the patients’age in most cases. Our results thus support the hypothesis that chronic periodontitis, represented by significant ABL, is an important and clinically relevant factor potentially associated with the development of OSCC.
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KEYWORD
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Chronic periodontitis, Oral cancer
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